DESCRIPTION :
Reducing methane (CH[4]) emissions from ruminants is a major challenge for the livestock sector. An optimal CH[4] mitigation strategy should also induce co-benefits such as enhanced animal productivity and health. CH[4] is produced during the fermentation of feeds in the rumen. This process is carried out by a complex microbial community (rumen microbiota) and mediated by hydrogen (H[2]) in the rumen ecosystem. Our knowledge on the drivers that shape H[2 ]flows is still incomplete. H[2]Rumen aims to generate fundamental knowledge on H[2] flows in the rumen ecosystem and to translate this knowledge into predictive mathematical models of rumen fermentation. Our scientific outputs will be of high value for the optimal design of CH[4] mitigation strategies with co-benefit for the animal. Our hypothesis is that thermodynamics and microbial interactions jointly control hydrogen transactions in the rumen ecosystem. H2Rumen addresses the
following fundamental scientific question: Where does H[2] go? We will answer this question with an integrative approach that combines in vitro experiments, in silico modelling and omics approaches. In addition to the impact on ruminant livestock, our methods might be applicable to other ecosystems such as the human gut, engineering bioreactors and fermented food ecosystems.
Mission confiée
The postdoc project aims at developing metabolic models of rumen microbiota with capabilities for designing microbial strategies for reducing methane emissions and improving rumen fermentation. It will contribute to fill the existing gap on how to integrate microbial genomic information into rumen fermentation models [1].
Genome-scale network reconstructions will be done with state-of-the-art methods and pipelines developed in PLEIADE. Metabolic capabilities of rumen microbial communities will be explored using Metage2Metabo [2]. Kinetic models will be built on the basis of existing models developed at MoSAR [3,4]. Models will be constructed using experimental data produced by our partners at UMRH and MoSAR.
[1] Muñoz-Tamayo R, Davoudkhani M, Fakih I, Robles-Rodriguez CE, Rubino F, Creevey CJ, et al. Review: Towards the next-generation models
of the rumen microbiome for enhancing predictive power and guiding sustainable production strategies. animal. 2023;17: 100984. doi:10.1016/J.ANIMAL.2023.100984
[2] Belcour A, Frioux C, Aite M, Bretaudeau A, Hildebrand F, Siegel A. Metage2metabo, microbiota-scale metabolic complementarity for the identification of key species. Elife. 2020;9: e61968. doi:10.7554/eLife.61968
[3] Muñoz-Tamayo R, Chagas JC, Ramin M, Krizsan SJ. Modelling the impact of the macroalgae Asparagopsis taxiformis on rumen microbial fermentation and methane production. Peer Community J. 2021;1: e7. doi:10.24072/PCJOURNAL.11
[4] Fakih I, Got J, Robles-Rodriguez CE, Siegel A, Forano E, Muñoz-Tamayo R. Dynamic genome-based metabolic modeling of the predominant cellulolytic rumen bacterium Fibrobacter succinogenes S85. mSystems. 2023;8: e01027-22. doi:10.1128/msystems.01027-22
Principales activités
The postdoc fellow will be part of the project H2Rumen funded by the French National Agency for Research (ANR). The specific objectives are
1. To obtain metabolic models of the species constituting a rumen microbial mini-consortium.
2. To derive a bag-of-genome model of a complex rumen consortium.
3. To develop a community-scale kinetic models of mini and complex consortia accounting for H2 transactions and thermodynamic control.
The work is organized in two parts. 18 months in PLEIADE to work on the objectives (i,ii) and 14 months at MoSAR to work on the objective (iii)., If you are interested by thi sjb, please could you apply on website jobs.inria with the following documents :
* cv
* cover letter
* recommendation letter
Sécurité défense :
Ce poste est susceptible d'être affecté dans une zone à régime restrictif (ZRR), telle que définie dans le décret n°2011-1425 relatif à la protection du potentiel scientifique et technique de la nation (PPST). L'autorisation d'accès à une zone est délivrée par le chef d'établissement, après avis ministériel favorable, tel que défini dans l'arrêté du 03 juillet 2012, relatif à la PPST. Un avis ministériel défavorable pour un poste affecté dans une ZRR aurait pour conséquence l'annulation du recrutement.
Politique de recrutement :
Dans le cadre de sa politique diversité, tous les postes Inria sont accessibles aux personnes en situation de handicap.
Code d'emploi : Chargé de Recherches (h/f)
Domaine professionnel actuel : Scientifiques
Niveau de formation : Bac+8
Temps partiel / Temps plein : Plein temps
Type de contrat : Contrat à durée indéterminée (CDI)
Compétences : Biologie Computationnelle, Données Expérimentales, Python (Langage de Programmation), MATLAB, Anglais, Français, Sens de la Communication, Curiosité, Mathématiques Appliquées, Bioréacteurs, Métabolisme, Génie des Procédés, Expérimentation, Génomique, Revue (Publication Périodique), Modélisation Mathématique, Conception Optimale, Recherche Post-Doctorale, Analyses Prédictives, Compétences de Modélisation, Publication / Edition
Courriel :
clemence.frioux@inria.fr
Téléphone :
0524574000
Type d'annonceur : Employeur direct